相互作用
Glimepiride + Sulfamethoxazole
重症度: 重大
Glimepiride and Sulfamethoxazole: major interaction.
最終更新日
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概要
Sulfamethoxazole, usually given with trimethoprim, can potentiate sulfonylureas and cause significant hypoglycemia. Cases are more frequent in older patients and those with renal dysfunction.
この相互作用をわかりやすく説明すると
Glimepiride and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
CYP2C9 inhibition by sulfamethoxazole reduces glimepiride clearance, with possible protein binding displacement.
対処法
Monitor blood glucose closely during co-trimoxazole therapy, reduce the glimepiride dose, or choose an alternative antibiotic in high-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GlimepirideとSulfamethoxazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glimepirideのその他の相互作用
よくある質問
Can I take Glimepiride with Sulfamethoxazole?
MediHelp rates the interaction as major. Glimepiride and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, can potentiate sulfonylureas and cause significant hypoglycemia. Cases are more frequent in older patients and those with renal dysfunction.
How serious is the interaction between Glimepiride and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-trimoxazole therapy, reduce the glimepiride dose, or choose an alternative antibiotic in high-risk patients.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
