相互作用
Fluconazole + Glimepiride
重症度: 重大
Fluconazole and Glimepiride: major interaction.
最終更新日
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概要
Fluconazole raises glimepiride concentrations, increasing the risk of prolonged and severe hypoglycemia. The effect is clinically important, particularly in older patients and those with renal impairment.
この相互作用をわかりやすく説明すると
Fluconazole and Glimepiride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glimepiride belongs to Endocrine.
なぜ起こるのか
Fluconazole inhibits CYP2C9, the main enzyme metabolizing glimepiride.
対処法
Monitor blood glucose closely and reduce the glimepiride dose when fluconazole is started. Counsel the patient on hypoglycemia symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluconazoleとGlimepirideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluconazoleのその他の相互作用
Glimepirideのその他の相互作用
よくある質問
Can I take Fluconazole with Glimepiride?
MediHelp rates the interaction as major. Fluconazole and Glimepiride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glimepiride concentrations, increasing the risk of prolonged and severe hypoglycemia. The effect is clinically important, particularly in older patients and those with renal impairment.
How serious is the interaction between Fluconazole and Glimepiride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glimepiride dose when fluconazole is started. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
