相互作用
Imipenem / cilastatin / relebactam + Valproic acid
重症度: 併用禁忌
Imipenem / cilastatin / relebactam and Valproic acid: contraindicated interaction.
最終更新日
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概要
Imipenem-containing regimens rapidly lower valproate concentrations and can cause loss of seizure control. The reduction can persist after the carbapenem is stopped and is hard to counter with valproate dose increases.
この相互作用をわかりやすく説明すると
Imipenem / cilastatin / relebactam and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Carbapenems inhibit acylpeptide hydrolase, blocking hydrolysis of valproate glucuronide back to valproate, and possibly reduce its absorption or increase its distribution into red cells.
対処法
Avoid the combination and choose a non-carbapenem antibiotic. If unavoidable, give alternative anticonvulsant cover and monitor valproate levels and seizures.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Imipenem / cilastatin / relebactamとValproic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Valproic acidのその他の相互作用
よくある質問
Can I take Imipenem / cilastatin / relebactam with Valproic acid?
MediHelp rates the interaction as contraindicated. Imipenem / cilastatin / relebactam and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Imipenem-containing regimens rapidly lower valproate concentrations and can cause loss of seizure control. The reduction can persist after the carbapenem is stopped and is hard to counter with valproate dose increases.
How serious is the interaction between Imipenem / cilastatin / relebactam and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-carbapenem antibiotic. If unavoidable, give alternative anticonvulsant cover and monitor valproate levels and seizures.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin, Meropenem / vaborbactam. The full list is on the Valproic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
