相互作用
Meropenem + Valproic acid
重症度: 併用禁忌
Meropenem and Valproic acid: contraindicated interaction.
最終更新日
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概要
Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
この相互作用をわかりやすく説明すると
Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meropenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
なぜ起こるのか
Carbapenems are thought to inhibit hydrolysis of valproate glucuronide back to valproate and may reduce its absorption and red cell uptake, lowering valproate concentrations.
対処法
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MeropenemとValproic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Meropenemのその他の相互作用
Valproic acidのその他の相互作用
よくある質問
Can I take Meropenem with Valproic acid?
MediHelp rates the interaction as contraindicated. Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
How serious is the interaction between Meropenem and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Typhoid vaccine live, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
