相互作用
Imipramine + Safinamide
重症度: 併用禁忌
Imipramine and Safinamide: contraindicated interaction.
最終更新日
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概要
Safinamide is a reversible MAO-B inhibitor and imipramine blocks serotonin and noradrenaline reuptake. The combination can cause life-threatening serotonin syndrome.
この相互作用をわかりやすく説明すると
Imipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
なぜ起こるのか
MAO-B inhibition plus monoamine reuptake inhibition
対処法
Contraindicated; allow at least 5 half-lives of safinamide (about 7 days) before starting imipramine and 14 days after stopping a tricyclic before safinamide.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ImipramineとSafinamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Imipramineのその他の相互作用
Safinamideのその他の相互作用
よくある質問
Can I take Imipramine with Safinamide?
MediHelp rates the interaction as contraindicated. Imipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a reversible MAO-B inhibitor and imipramine blocks serotonin and noradrenaline reuptake. The combination can cause life-threatening serotonin syndrome.
How serious is the interaction between Imipramine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 5 half-lives of safinamide (about 7 days) before starting imipramine and 14 days after stopping a tricyclic before safinamide.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
