相互作用
Insulin degludec + Megestrol
重症度: 中等度
Insulin degludec and Megestrol: moderate interaction.
最終更新日
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概要
Megestrol, particularly at higher doses used for appetite stimulation, can raise blood glucose through glucocorticoid-like activity and reduce insulin effectiveness. Insulin requirements may rise.
この相互作用をわかりやすく説明すると
Insulin degludec and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Megestrol belongs to Oncology.
なぜ起こるのか
Megestrol has glucocorticoid-like activity that promotes insulin resistance and hyperglycemia, opposing insulin action.
対処法
Monitor blood glucose when starting, adjusting or stopping megestrol and increase the insulin dose as needed. Reduce the insulin dose again after megestrol is discontinued.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Insulin degludecとMegestrolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Insulin degludecのその他の相互作用
Megestrolのその他の相互作用
よくある質問
Can I take Insulin degludec with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol, particularly at higher doses used for appetite stimulation, can raise blood glucose through glucocorticoid-like activity and reduce insulin effectiveness. Insulin requirements may rise.
How serious is the interaction between Insulin degludec and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, adjusting or stopping megestrol and increase the insulin dose as needed. Reduce the insulin dose again after megestrol is discontinued.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
