医薬品リファレンス
Megestrol
Megestrol is a medicine in the class oncology. It is used for breast cancer.
- 薬効分類: Oncology
- 効能・効果: breast cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 錠剤
- 一般的な規格
- 160 mg
- 既知の相互作用
- 9 (併用禁忌: 1 · 中等度: 7 · 軽度: 1)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Progestin derivative with antiestrogenic properties; interferes with estrogen cycle, resulting in lower luteinizing hormone (LH) titer; antineoplastic properties may come from direct effect on endometrium through anti-LH effect mediated via pituitary
成人の通常用量（添付文書の要約）
AIDS-Related Cachexia (Megace): 800 mg/day PO
妊娠と授乳
- 妊娠
- Unsafe Avoid: progestogen; rats showed fewer live births and feminised male fetuses, and early-pregnancy progestogen exposure has been linked to hypospadias. UK label: not recommended in pregnancy. Women who could become pregnant should use contraception.
- 授乳
- Unknown No LactMed or e-lactancia record. US and UK labels: stop breastfeeding during treatment because of possible effects on the newborn. Prefer not to breastfeed while taking it.
報告されている副作用
- Thrombophlebitis
- Hypertension
- Insomnia
- Mood swings
- Amenorrhea
- Rash
禁忌
- Known or suspected pregnancy
- Acute thrombophlebitis, thromboembolic disorder, breast cancer
- Undiagnosed abnormal genital bleeding
注意が必要な方
- Adrenal insufficiency may occur in patients receiving or being withdrawn from long-term megestrol treatment
- Megestrol is a progesterone derivative which may induce vaginal bleeding in women
- Cushing syndrome reported
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (9)
- Dofetilide + Megestrol Contraindicated
- Insulin degludec + Megestrol Moderate
- Insulin degludec / insulin aspart + Megestrol Moderate
- Insulin degludec-insulin aspart + Megestrol Moderate
- Insulin degludec-liraglutide + Megestrol Moderate
- Insulin inhaled + Megestrol Moderate
- Mavacamten + Megestrol Moderate
- Megestrol + Warfarin Moderate
- Maitake + Megestrol Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Megestrolの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Megestrol used for?
Megestrol is a medicine in the class oncology. It is used for Breast cancer, Cachexia, Endometrial carcinoma.
What side effects have been reported with Megestrol?
Thrombophlebitis, Hypertension, Insomnia, Mood swings, Amenorrhea, Rash.
Can Megestrol be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Avoid: progestogen; rats showed fewer live births and feminised male fetuses, and early-pregnancy progestogen exposure has been linked to hypospadias. UK label: not recommended in pregnancy. Women who could become pregnant should use contraception. Breastfeeding: Unknown. No LactMed or e-lactancia record. US and UK labels: stop breastfeeding during treatment because of possible effects on the newborn. Prefer not to breastfeed while taking it.
What does Megestrol interact with?
MediHelp lists 9 known interactions for Megestrol. Contraindicated: 1 · Moderate: 7 · Minor: 1. The most serious include Dofetilide, Insulin degludec, Insulin degludec / insulin aspart.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
