相互作用
Lorlatinib + Pentobarbital
重症度: 併用禁忌
Lorlatinib and Pentobarbital: contraindicated interaction.
最終更新日
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概要
Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
この相互作用をわかりやすく説明すると
Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Induction of CYP3A4 accelerates lorlatinib metabolism and lowers exposure.
対処法
Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、LorlatinibとPentobarbitalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lorlatinibのその他の相互作用
よくある質問
Can I take Lorlatinib with Pentobarbital?
MediHelp rates the interaction as contraindicated. Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Lorlatinib and Pentobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
