相互作用
Maprotiline + Methylene blue
重症度: 併用禁忌
Maprotiline and Methylene blue: contraindicated interaction.
最終更新日
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概要
Methylene blue inhibits monoamine oxidase A, so combining it with a serotonergic antidepressant can cause serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability. The reaction can be severe.
この相互作用をわかりやすく説明すると
Maprotiline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
MAO-A inhibition by methylene blue combined with maprotiline's norepinephrine reuptake blockade increases monoamine activity.
対処法
Avoid unless urgent treatment is essential; if needed, stop maprotiline and monitor for CNS toxicity. Serotonergic therapy can be resumed 24 hours after the last methylene blue dose, or sooner if toxicity is absent after 2 weeks of monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MaprotilineとMethylene blueの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Maprotilineのその他の相互作用
よくある質問
Can I take Maprotiline with Methylene blue?
MediHelp rates the interaction as contraindicated. Maprotiline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, so combining it with a serotonergic antidepressant can cause serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability. The reaction can be severe.
How serious is the interaction between Maprotiline and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless urgent treatment is essential; if needed, stop maprotiline and monitor for CNS toxicity. Serotonergic therapy can be resumed 24 hours after the last methylene blue dose, or sooner if toxicity is absent after 2 weeks of monitoring.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
