相互作用
Dofetilide + Maprotiline
重症度: 併用禁忌
Dofetilide and Maprotiline: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Dofetilide causes dose-related QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination may lead to life-threatening arrhythmia.
この相互作用をわかりやすく説明すると
Dofetilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation through delayed cardiac repolarization.
対処法
Avoid the combination and choose an antidepressant with minimal QT effect. Dofetilide is started under continuous ECG monitoring in hospital.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DofetilideとMaprotilineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Maprotilineのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Dofetilide with Maprotiline?
MediHelp rates the interaction as contraindicated. Dofetilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide causes dose-related QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination may lead to life-threatening arrhythmia.
How serious is the interaction between Dofetilide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with minimal QT effect. Dofetilide is started under continuous ECG monitoring in hospital.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Ibutilide. The full list is on the Maprotiline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
