相互作用
Methotrexate + Probenecid
重症度: 重大
Methotrexate and Probenecid: major interaction.
最終更新日
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概要
Probenecid reduces the renal elimination of methotrexate, leading to higher and more prolonged methotrexate concentrations. This can cause severe myelosuppression, mucositis and renal or hepatic toxicity, particularly at higher methotrexate doses.
この相互作用をわかりやすく説明すると
Methotrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methotrexate belongs to Oncology; Probenecid belongs to Genitourinary.
なぜ起こるのか
Probenecid inhibits organic anion transporters (OAT1/OAT3) in the renal tubule, blocking tubular secretion of methotrexate and its metabolites.
対処法
Avoid the combination where possible; if it is unavoidable, reduce the methotrexate dose and monitor blood counts, renal function and methotrexate levels closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MethotrexateとProbenecidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methotrexateのその他の相互作用
Probenecidのその他の相互作用
よくある質問
Can I take Methotrexate with Probenecid?
MediHelp rates the interaction as major. Methotrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid reduces the renal elimination of methotrexate, leading to higher and more prolonged methotrexate concentrations. This can cause severe myelosuppression, mucositis and renal or hepatic toxicity, particularly at higher methotrexate doses.
How serious is the interaction between Methotrexate and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is unavoidable, reduce the methotrexate dose and monitor blood counts, renal function and methotrexate levels closely.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
