医薬品リファレンス
Probenecid
Probenecid is a medicine in the class genitourinary. It is used for gonorrhea.
- 薬効分類: Genitourinary
- 効能・効果: gonorrhea
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Genitourinary
- 既知の相互作用
- 161 (併用禁忌: 2 · 重大: 6 · 中等度: 92 · 軽度: 61)
何に使われるか
作用のしくみ
(Uricosuric) inhibits tubular reabsorption of urate; increasing uric acid excretion, Also inhibits tubular secretion of weak organic acids like PCNs & cephalosporins
成人の通常用量（添付文書の要約）
Gout: 250 mg PO twice daily for 1 week; increase to 500 mg PO twice daily to 2 g/day maximum with dosage increases of 500 mg q4weeks
妊娠と授乳
- 妊娠
- Safe Crosses the placenta and appears in cord blood; no reports of fetal harm. US label: weigh benefit against possible hazards. It has long been used with penicillin or cephalosporins to treat infections in pregnancy. Acceptable when needed.
- 授乳
- Safe Low milk levels at doses up to 2 g daily; not expected to affect the infant, especially after 2 months of age (LactMed). It may raise milk levels of drugs given with it (seen in animals). Acceptable while breastfeeding.
報告されている副作用
- Headache
- Vomiting
- Nausea
- Loss of appetite
- GI upset
禁忌
- Age <2 years
- Uric acid kidney stones, acute gouty arthritis
- Hypersensitivity
注意が必要な方
- Use caution in patients with G6PD deficiency; may increase risk for hemolytic anemia
- Salicylates may reduce the therapeutic effects of probenecid (effect may be pronounced with high chronic doses
- May cause exacerbation of acute gouty attack; in such cases colchicine or other appropriate therapy is advisable
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (161)
- Ketorolac + Probenecid Contraindicated
- Ketorolac intranasal + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
- Probenecid + Roxadustat Major
- Probenecid + Valganciclovir Major
- Aceclofenac + Probenecid Moderate
- Acemetacin + Probenecid Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Probenecidの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Probenecid used for?
Probenecid is a medicine in the class genitourinary. It is used for Gonorrhea, Gout, Pelvic inflammatory disease, Prolong penicillin serum levels.
What side effects have been reported with Probenecid?
Headache, Vomiting, Nausea, Loss of appetite, GI upset.
Can Probenecid be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Crosses the placenta and appears in cord blood; no reports of fetal harm. US label: weigh benefit against possible hazards. It has long been used with penicillin or cephalosporins to treat infections in pregnancy. Acceptable when needed. Breastfeeding: Safe. Low milk levels at doses up to 2 g daily; not expected to affect the infant, especially after 2 months of age (LactMed). It may raise milk levels of drugs given with it (seen in animals). Acceptable while breastfeeding.
What does Probenecid interact with?
MediHelp lists 161 known interactions for Probenecid. Contraindicated: 2 · Major: 6 · Moderate: 92 · Minor: 61. The most serious include Ketorolac, Ketorolac intranasal, Baricitinib.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
