相互作用
Methylene blue + Venlafaxine
重症度: 併用禁忌
Methylene blue and Venlafaxine: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Methylene blue is a potent MAO-A inhibitor and, combined with serotonin reuptake inhibitors like venlafaxine, can cause severe serotonin syndrome. Reactions have occurred with intravenous methylene blue given for methemoglobinemia or during surgery.
この相互作用をわかりやすく説明すると
Methylene blue and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
MAO-A inhibition by methylene blue added to serotonin reuptake inhibition.
対処法
Avoid unless methylene blue is needed for an emergency; then stop venlafaxine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Methylene blueとVenlafaxineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Venlafaxineのその他の相互作用
よくある質問
Can I take Methylene blue with Venlafaxine?
MediHelp rates the interaction as contraindicated. Methylene blue and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue is a potent MAO-A inhibitor and, combined with serotonin reuptake inhibitors like venlafaxine, can cause severe serotonin syndrome. Reactions have occurred with intravenous methylene blue given for methemoglobinemia or during surgery.
How serious is the interaction between Methylene blue and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; then stop venlafaxine and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Venlafaxine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
