相互作用
Rasagiline + Venlafaxine
重症度: 併用禁忌
Rasagiline and Venlafaxine: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Rasagiline is a selective MAO-B inhibitor that, at higher doses, loses selectivity, and combined use with serotonergic antidepressants has been linked to serotonin syndrome. Venlafaxine labeling warns against its use with MAO inhibitors, and severe hyperthermia and CNS toxicity can occur.
この相互作用をわかりやすく説明すると
Rasagiline and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
なぜ起こるのか
Inhibition of monoamine metabolism combined with serotonin and norepinephrine reuptake inhibition produces additive serotonergic excess.
対処法
Avoid concomitant use. Allow at least 14 days after stopping rasagiline before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting rasagiline.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、RasagilineとVenlafaxineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Venlafaxineのその他の相互作用
Rasagilineのその他の相互作用
よくある質問
Can I take Rasagiline with Venlafaxine?
MediHelp rates the interaction as contraindicated. Rasagiline and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline is a selective MAO-B inhibitor that, at higher doses, loses selectivity, and combined use with serotonergic antidepressants has been linked to serotonin syndrome. Venlafaxine labeling warns against its use with MAO inhibitors, and severe hyperthermia and CNS toxicity can occur.
How serious is the interaction between Rasagiline and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Allow at least 14 days after stopping rasagiline before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting rasagiline.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
