相互作用
Modafinil + Nirogacestat
重症度: 重大
Modafinil and Nirogacestat: major interaction.
最終更新日
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概要
Modafinil may reduce nirogacestat exposure and therefore its efficacy in desmoid tumors. Labeling advises avoiding moderate CYP3A inducers.
この相互作用をわかりやすく説明すると
Modafinil and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Nirogacestat belongs to Oncology.
なぜ起こるのか
Modafinil induces CYP3A4, increasing nirogacestat clearance.
対処法
Avoid the combination and use a non-inducing alternative where possible. If used together, monitor tumor response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ModafinilとNirogacestatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Modafinilのその他の相互作用
Nirogacestatのその他の相互作用
よくある質問
Can I take Modafinil with Nirogacestat?
MediHelp rates the interaction as major. Modafinil and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil may reduce nirogacestat exposure and therefore its efficacy in desmoid tumors. Labeling advises avoiding moderate CYP3A inducers.
How serious is the interaction between Modafinil and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative where possible. If used together, monitor tumor response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
