相互作用
Moexipril + Sacubitril-valsartan
重症度: 併用禁忌
Moexipril and Sacubitril-valsartan: contraindicated interaction.
最終更新日
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概要
Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.
この相互作用をわかりやすく説明すると
Moexipril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Moexipril belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
なぜ起こるのか
Both neprilysin and ACE degrade bradykinin; inhibiting both increases bradykinin levels.
対処法
Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MoexiprilとSacubitril-valsartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sacubitril-valsartanのその他の相互作用
Moexiprilのその他の相互作用
よくある質問
Can I take Moexipril with Sacubitril-valsartan?
MediHelp rates the interaction as contraindicated. Moexipril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.
How serious is the interaction between Moexipril and Sacubitril-valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
