相互作用
Palonosetron + Tranylcypromine
重症度: 重大
Palonosetron and Tranylcypromine: major interaction.
最終更新日
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概要
Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.
この相互作用をわかりやすく説明すると
Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palonosetron belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
なぜ起こるのか
Additive serotonergic effects on top of irreversible MAO inhibition; the contribution of 5-HT3 antagonists is not firmly established.
対処法
Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PalonosetronとTranylcypromineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Palonosetronのその他の相互作用
Tranylcypromineのその他の相互作用
よくある質問
Can I take Palonosetron with Tranylcypromine?
MediHelp rates the interaction as major. Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.
How serious is the interaction between Palonosetron and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
