相互作用
Phenindione + Vitamin e
重症度: 中等度
Phenindione and Vitamin e: moderate interaction.
最終更新日
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概要
Phenindione is an oral vitamin K antagonist, and high doses of vitamin E may further impair vitamin K-dependent clotting and platelet function. This may increase bleeding risk, mainly with megadoses.
この相互作用をわかりやすく説明すると
Phenindione and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
High-dose vitamin E antagonizes vitamin K-dependent clotting factor synthesis and inhibits platelet aggregation, adding to phenindione's effect.
対処法
Avoid vitamin E megadoses in patients on phenindione. Monitor INR and bleeding signs if supplementation is started or stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PhenindioneとVitamin eの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vitamin eのその他の相互作用
よくある質問
Can I take Phenindione with Vitamin e?
MediHelp rates the interaction as moderate. Phenindione and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenindione is an oral vitamin K antagonist, and high doses of vitamin E may further impair vitamin K-dependent clotting and platelet function. This may increase bleeding risk, mainly with megadoses.
How serious is the interaction between Phenindione and Vitamin e?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin E megadoses in patients on phenindione. Monitor INR and bleeding signs if supplementation is started or stopped.
What other medicines interact with Vitamin e?
MediHelp also lists interactions of Vitamin e with, for example, Betrixaban, Selumetinib, Warfarin. The full list is on the Vitamin e page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
