Referência de medicamentos
Dapagliflozin-saxagliptin
Dapagliflozin-saxagliptin is a medicine in the class gastrointestinal tract. It is used for diabetes mellitus.
- Classe do medicamento: Gastrointestinal Tract
- Indicado para: diabetes mellitus
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Gastrointestinal Tract
- Código ATC
- A10BD21
- Formas farmacêuticas comuns
- comprimido
- Concentrações comuns
- 5 mg
- Nomes comerciais
- 3
- Países e mercados
- 3
Para que é usado
Como funciona
Dapagliflozin: Selective sodium-glucose transporter-2 (SGLT2) inhibitor; SGLT-2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen; SGLT2 inhibitors reduce glucose reabsorption and lower the renal threshold for glucose, thereby increasing urinary glucose excretion
Dose habitual em adultos (resumo da bula)
Type 2 Diabetes Mellitus: 1 tablet (ie, 10mg/5mg) PO qDay in AM with or without food
Gravidez e amamentação
- Gravidez
- Unsafe Dapagliflozin: kidney changes in rat offspring; not recommended in the 2nd and 3rd trimesters. Saxagliptin: limited data, no harm in animals. Stop the combination when pregnancy is detected; insulin is preferred.
- Amamentação
- Unsafe No human milk data for either component; both pass into rat milk. Because of possible serious infant reactions (dapagliflozin and kidney maturation), the US label advises not to breastfeed.
Efeitos adversos relatados
- Diarrhea
- Back Pain
- Upper respiratory tract infection (URI)
- Urinary tract infections
- Dyslipidemia
- Headaches
Contraindicações
- History of hypersensitivity to dapagliflozin or saxagliptin, including anaphylaxis, angioedema, or exfoliative skin conditions
- Moderate-to-severe renal impairment (eGFR <45 mL/min/1.73 m²), end-stage renal disease, or patients on dialysis
Quem deve ter cuidado
- Acute pancreatitis reported; after initiating drug, monitor for signs and symptoms of pancreatitis; if suspected, promptly discontinue dapagliflozin/saxagliptin and initiate appropriate management
- May increase risk for developing heart failure (HF) or exacerbation of existing HR; observe patients for signs and symptoms of HF
- Serious urinary tract infections including urosepsis and pyelonephritis requiring hospitalization reported in patients receiving SGLT2 inhibitors, including dapagliflozin; treatment with SGLT2 inhibitors increases risk for urinary tract infections; evaluate patients for signs and symptoms of urinary tract infections and treat promptly, if indicated
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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Outros medicamentos desta classe
Perguntas frequentes
What is Dapagliflozin-saxagliptin used for?
Dapagliflozin-saxagliptin is a medicine in the class gastrointestinal tract. It is used for Diabetes mellitus.
What side effects have been reported with Dapagliflozin-saxagliptin?
Diarrhea, Back Pain, Upper respiratory tract infection (URI), Urinary tract infections, Dyslipidemia, Headaches.
Can Dapagliflozin-saxagliptin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Dapagliflozin: kidney changes in rat offspring; not recommended in the 2nd and 3rd trimesters. Saxagliptin: limited data, no harm in animals. Stop the combination when pregnancy is detected; insulin is preferred. Breastfeeding: Unsafe. No human milk data for either component; both pass into rat milk. Because of possible serious infant reactions (dapagliflozin and kidney maturation), the US label advises not to breastfeed.
What does Dapagliflozin-saxagliptin interact with?
MediHelp does not list a checked interaction for Dapagliflozin-saxagliptin yet. Always tell your pharmacist about every medicine you take.
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