Referência de medicamentos
Nifurtimox
Nifurtimox is a medicine in the class anti parasitic.
- Classe do medicamento: Anti Parasitic
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Anti Parasitic
- Formas farmacêuticas comuns
- comprimido
- Nomes comerciais
- 1
- Países e mercados
- 1
Como funciona
Mechanism not fully understood. Nifurtimox is activated by type I and type II nitroreductases, producing toxic intermediate metabolites and/or reactive oxygen species that induce DNA damage and cell death of intracellular and extracellular T. cruzi.
Gravidez e amamentação
- Gravidez
- Unsafe May cause fetal harm based on animal studies; treatment of chronic Chagas disease in pregnancy not recommended; acute symptomatic disease requires case-by-case risk-benefit evaluation.
- Amamentação
- Unknown Nifurtimox is present in breast milk (estimated infant dose less than 15% of the pediatric daily dose); monitor infants for vomiting, rash, decreased appetite, pyrexia and irritability; weigh benefits of breastfeeding against maternal need.
Efeitos adversos relatados
- Vomiting
- Abdominal pain
- Headache
- Decreased appetite
- Nausea
- Pyrexia
Contraindicações
- Known hypersensitivity to nifurtimox or any excipients
- Alcohol consumption during treatment
Quem deve ter cuidado
- Genotoxicity demonstrated in humans, in vitro and in rodents; carcinogenicity in humans unknown.
- Embryo-fetal toxicity: can cause fetal harm; pregnancy test before treatment; effective contraception during treatment and for 6 months after; males use condoms during and for 3 months after.
- May worsen neurological and psychiatric conditions (brain injury, seizures, psychiatric disease); use under close medical supervision.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para abrir a monografia completa de Nifurtimox: doses, gravidez e amamentação, efeitos adversos, advertências e todas as interações.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outros medicamentos desta classe
Perguntas frequentes
What is Nifurtimox used for?
Nifurtimox is a medicine in the class anti parasitic.
What side effects have been reported with Nifurtimox?
Vomiting, Abdominal pain, Headache, Decreased appetite, Nausea, Pyrexia.
Can Nifurtimox be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on animal studies; treatment of chronic Chagas disease in pregnancy not recommended; acute symptomatic disease requires case-by-case risk-benefit evaluation. Breastfeeding: Unknown. Nifurtimox is present in breast milk (estimated infant dose less than 15% of the pediatric daily dose); monitor infants for vomiting, rash, decreased appetite, pyrexia and irritability; weigh benefits of breastfeeding against maternal need.
What does Nifurtimox interact with?
MediHelp does not list a checked interaction for Nifurtimox yet. Always tell your pharmacist about every medicine you take.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
