Referência de medicamentos
Pentamidine
Pentamidine is a medicine in the class anti parasitic. It is used for pneumonia.
- Classe do medicamento: Anti Parasitic
- Indicado para: pneumonia
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Anti Parasitic
- Formas farmacêuticas comuns
- injeção, inalador
- Concentrações comuns
- 300 mg/3 ml, 300 mg/6 ml
- Interações conhecidas
- 156 (Contraindicada: 9 · Grave: 113 · Moderada: 33 · Leve: 1)
- Nomes comerciais
- 2
- Países e mercados
- 1
Para que é usado
Como funciona
Aromatic diamidine; mode of action not fully understood. In vitro it interferes with protozoal nuclear metabolism by inhibiting DNA, RNA, phospholipid and protein synthesis.
Dose habitual em adultos (resumo da bula)
Pneumocystis carinii pneumonia: 4 mg/kg once a day, IM or IV, for 14 to 21 days; therapy longer than 21 days may be associated with increased toxicity
Gravidez e amamentação
- Gravidez
- Unknown Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first.
- Amamentação
- Unknown Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.
Efeitos adversos relatados
- Elevated serum creatinine
- Impaired renal function
- Sterile abscess, necrosis, pain or induration at IM site
- Leukopenia
- Elevated liver function tests
- Azotemia
Contraindicações
- History of hypersensitivity to pentamidine isethionate.
Quem deve ter cuidado
- Fatalities from severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported with IM and IV use; limit use to patients with demonstrated Pneumocystis carinii.
- Sudden severe hypotension can occur after a single dose; patients should lie down with close blood pressure monitoring and resuscitation equipment available.
- Extravasation may cause ulceration, tissue necrosis or sloughing; discontinue the infusion and restart in another vein.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (156)
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Pentamidine + Ziprasidone Contraindicated
- Adefovir + Pentamidine Major
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para abrir a monografia completa de Pentamidine: doses, gravidez e amamentação, efeitos adversos, advertências e todas as interações.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outros medicamentos desta classe
Perguntas frequentes
What is Pentamidine used for?
Pentamidine is a medicine in the class anti parasitic. It is used for Pneumonia.
What side effects have been reported with Pentamidine?
Elevated serum creatinine, Impaired renal function, Sterile abscess, necrosis, pain or induration at IM site, Leukopenia, Elevated liver function tests, Azotemia.
Can Pentamidine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.
What does Pentamidine interact with?
MediHelp lists 156 known interactions for Pentamidine. Contraindicated: 9 · Major: 113 · Moderate: 33 · Minor: 1. The most serious include Clomipramine, Desipramine, Dronedarone.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
