Referência de medicamentos
Somapacitan
Somapacitan is a medicine in the class endocrine. It is used for growth failure.
- Classe do medicamento: Endocrine
- Indicado para: growth failure
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Endocrine
- Código ATC
- H01AC07
- Formas farmacêuticas comuns
- injeção
- Interações conhecidas
- 101 (Moderada: 62 · Leve: 39)
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Somapacitan-beco binds to a dimeric GH receptor on target cells, causing intracellular signal transduction. Some effects are mediated mainly by IGF-1 produced in the liver, others are direct effects of somapacitan-beco.
Dose habitual em adultos (resumo da bula)
Adult GHD: start 1.5 mg subcutaneously once weekly (treatment-naive or switching from daily GH); increase every 2 to 4 weeks by approximately 0.5 mg to 1.5 mg based on clinical response and IGF-1; maximum 8 mg once weekly
Gravidez e amamentação
- Gravidez
- Unknown No data for this long-acting growth hormone; decades of short-acting growth hormone use in pregnancy show no drug-related risk, and animals showed no birth defects. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed.
- Amamentação
- Unknown No human data; it passes into rat milk. UK label: decide whether to stop breastfeeding or the drug. LactMed: a large, poorly absorbed molecule unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
Efeitos adversos relatados
- Nasopharyngitis
- Headache
- Pyrexia
- Pain in extremity
- Injection site reaction
- Cough
Contraindicações
- Acute critical illness after open-heart surgery, abdominal surgery or multiple accidental trauma, or acute respiratory failure
- Hypersensitivity to SOGROYA or any of its excipients
- Pediatric patients with closed epiphyses
Quem deve ter cuidado
- Increased mortality in acute critical illness
- Severe hypersensitivity including anaphylaxis and angioedema may occur
- Neoplasm risk: monitor patients with preexisting tumors; second neoplasm risk in childhood cancer survivors
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (101)
- Alogliptin + Somapacitan Moderate
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
- Cyclosporin + Somapacitan Moderate
- Dapagliflozin-metformin + Somapacitan Moderate
- Deflazacort + Somapacitan Moderate
- Desogestrel-ethinyl estradiol + Somapacitan Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Outros medicamentos desta classe
Perguntas frequentes
What is Somapacitan used for?
Somapacitan is a medicine in the class endocrine. It is used for Growth failure, Growth hormone deficiency.
What side effects have been reported with Somapacitan?
Nasopharyngitis, Headache, Pyrexia, Pain in extremity, Injection site reaction, Cough.
Can Somapacitan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No data for this long-acting growth hormone; decades of short-acting growth hormone use in pregnancy show no drug-related risk, and animals showed no birth defects. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed. Breastfeeding: Unknown. No human data; it passes into rat milk. UK label: decide whether to stop breastfeeding or the drug. LactMed: a large, poorly absorbed molecule unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
What does Somapacitan interact with?
MediHelp lists 101 known interactions for Somapacitan. Moderate: 62 · Minor: 39. The most serious include Alogliptin, Alogliptin-metformin, Alogliptin-pioglitazone.
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