Interações medicamentosas
Deflazacort + Somapacitan
Gravidade: Moderada
Deflazacort and Somapacitan: moderate interaction.
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Resumo
Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
O que esta interação significa em palavras simples
Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somapacitan belongs to Endocrine.
Por que acontece
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 reducing cortisol activation.
O que fazer
Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicada
- Bcg vaccine live + Deflazacort Contraindicada
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Deflazacort + Measles mumps and rubella vaccine Contraindicada
- Deflazacort + Measles mumps and rubella vaccine live Contraindicada
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicada
Outras interações de Somapacitan
- Alogliptin-metformin + Somapacitan Moderada
- Alogliptin-pioglitazone + Somapacitan Moderada
- Alogliptin + Somapacitan Moderada
- Bazedoxifene-conjugated estrogens + Somapacitan Moderada
- Canagliflozin-metformin + Somapacitan Moderada
- Chlorpropamide + Somapacitan Moderada
Perguntas frequentes
Can I take Deflazacort with Somapacitan?
MediHelp rates the interaction as moderate. Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
How serious is the interaction between Deflazacort and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
Monografias completas, posologia e verificador de interações no app MediHelp
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