Referência de medicamentos
Telotristat etiprate
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for diarrhea.
- Classe do medicamento: Gastrointestinal Tract
- Indicado para: diarrhea
Última atualização Fontes: EMA SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Gastrointestinal Tract
- Interações conhecidas
- 12 (Moderada: 10 · Leve: 2)
- Nomes comerciais
- 1
- Países e mercados
- 1
Para que é usado
Como funciona
Telotristat ethyl and its active metabolite telotristat inhibit L-tryptophan hydroxylases (TPH1 and TPH2), the rate-limiting steps in serotonin biosynthesis. By inhibiting peripheral TPH1 it reduces serotonin production and eases carcinoid syndrome symptoms.
Dose habitual em adultos (resumo da bula)
Carcinoid syndrome diarrhoea (with somatostatin analogue therapy, adults inadequately controlled by SSA): 250 mg orally three times daily; higher doses not recommended; reassess benefit if no response within 12 weeks
Gravidez e amamentação
- Gravidez
- Unknown No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception.
- Amamentação
- Unknown No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
Efeitos adversos relatados
- Abdominal pain
- Gamma-glutamyl transferase increased
- Fatigue
- Abdominal distension
- Flatulence
- Constipation
Contraindicações
- Hypersensitivity to the active substance or to any excipients.
Quem deve ter cuidado
- Hepatic enzyme elevations: monitor liver enzymes before and during therapy as clinically indicated; discontinue if liver injury is suspected and do not resume unless another cause is found.
- Constipation: telotristat reduces bowel movement frequency; monitor for constipation and re-evaluate therapy if it develops.
- Depressive disorders: depression, depressed mood and decreased interest reported; patients should report symptoms.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (12)
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
- Prasugrel + Telotristat etiprate Moderate
- Simvastatin + Telotristat etiprate Moderate
- Sodium valproate + Telotristat etiprate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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Perguntas frequentes
What is Telotristat etiprate used for?
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for Diarrhea.
What side effects have been reported with Telotristat etiprate?
Abdominal pain, Gamma-glutamyl transferase increased, Fatigue, Abdominal distension, Flatulence, Constipation.
Can Telotristat etiprate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception. Breastfeeding: Unknown. No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
What does Telotristat etiprate interact with?
MediHelp lists 12 known interactions for Telotristat etiprate. Moderate: 10 · Minor: 2. The most serious include Bupropion, Capecitabine, Everolimus.
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