Interações medicamentosas
Capecitabine + Telotristat etiprate
Gravidade: Moderada
Capecitabine and Telotristat etiprate: moderate interaction.
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Resumo
Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
O que esta interação significa em palavras simples
Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
Por que acontece
Possible modulation of CES2-mediated metabolism of capecitabine; the effect has not been clearly established clinically.
O que fazer
Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Telotristat etiprate
- Bupropion + Telotristat etiprate Moderada
- Everolimus + Telotristat etiprate Moderada
- Flutamide + Telotristat etiprate Moderada
- Irinotecan + Telotristat etiprate Moderada
- Midazolam + Telotristat etiprate Moderada
- Octreotide + Telotristat etiprate Moderada
Outras interações de Capecitabine
Perguntas frequentes
Can I take Capecitabine with Telotristat etiprate?
MediHelp rates the interaction as moderate. Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
How serious is the interaction between Capecitabine and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
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