Referência de medicamentos
Tislelizumab
Tislelizumab is a medicine in the class oncology. It is used for gastric cancer.
- Classe do medicamento: Oncology
- Indicado para: gastric cancer
Última atualização Fontes: EMA SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Oncology
- Código ATC
- L01FF09
- Formas farmacêuticas comuns
- injeção
- Concentrações comuns
- 10 mg/ml
- Interações conhecidas
- 6 (Moderada: 5 · Leve: 1)
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Humanised IgG4 variant monoclonal antibody against PD-1 that binds the extracellular domain of human PD-1 and competitively blocks binding of PD-L1 and PD-L2. This inhibits PD-1-mediated negative signalling and enhances T-cell functional activity in in vitro assays.
Dose habitual em adultos (resumo da bula)
Monotherapy: 200 mg once every 3 weeks or 400 mg once every 6 weeks, intravenous infusion; treat until disease progression or unacceptable toxicity
Gravidez e amamentação
- Gravidez
- Unsafe No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment.
- Amamentação
- Unsafe Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
Efeitos adversos relatados
- Anaemia
- Aspartate aminotransferase increased
- Fatigue
- Alanine aminotransferase increased
- Neutropenia (with chemotherapy)
- Thrombocytopenia (with chemotherapy)
Contraindicações
- Hypersensitivity to the active substance or to any excipient.
Quem deve ter cuidado
- Immune-related adverse reactions, including fatal cases, can affect any organ system and may occur after the last dose; evaluate and withhold, with corticosteroids as needed.
- Immune-related pneumonitis, including fatal cases; monitor for signs and symptoms.
- Immune-related hepatitis; perform liver function tests at baseline and periodically.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (6)
- Amoxicillin + Tislelizumab Moderate
- Amoxicillin-clavulanic acid + Tislelizumab Moderate
- Piperacillin + Tislelizumab Moderate
- Piperacillin-tazobactam + Tislelizumab Moderate
- Prednisone + Tislelizumab Moderate
- Penicillin g + Tislelizumab Minor
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para abrir a monografia completa de Tislelizumab: doses, gravidez e amamentação, efeitos adversos, advertências e todas as interações.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outros medicamentos desta classe
Perguntas frequentes
What is Tislelizumab used for?
Tislelizumab is a medicine in the class oncology. It is used for Gastric cancer, Lung cancer, Non-small cell lung cancer.
What side effects have been reported with Tislelizumab?
Anaemia, Aspartate aminotransferase increased, Fatigue, Alanine aminotransferase increased, Neutropenia (with chemotherapy), Thrombocytopenia (with chemotherapy).
Can Tislelizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment. Breastfeeding: Unsafe. Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
What does Tislelizumab interact with?
MediHelp lists 6 known interactions for Tislelizumab. Moderate: 5 · Minor: 1. The most serious include Amoxicillin, Amoxicillin-clavulanic acid, Piperacillin.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
