Referência de medicamentos
Zuranolone
Zuranolone is a medicine in the class central nervous system. It is used for depression.
- Classe do medicamento: Central Nervous System
- Indicado para: depression
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Central Nervous System
- Formas farmacêuticas comuns
- cápsula
- Interações conhecidas
- 147 (Grave: 52 · Moderada: 93 · Leve: 2)
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Neuroactive steroid GABA A receptor positive modulator; its mechanism in postpartum depression is not fully understood but is thought to be related to positive allosteric modulation of GABA A receptors.
Dose habitual em adultos (resumo da bula)
Postpartum depression: 50 mg orally once daily in the evening for 14 days, with fat-containing food; consider reducing to 40 mg once daily if CNS depressant effects occur; can be used alone or as adjunct to oral antidepressants
Gravidez e amamentação
- Gravidez
- Unsafe May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists.
- Amamentação
- Unknown Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.
Efeitos adversos relatados
- Somnolence
- Dizziness
- Diarrhea
- Fatigue
- Nasopharyngitis
- Urinary tract infection
Advertências de caixa preta
- Causes driving impairment due to CNS depressant effects. Patients should not drive or engage in other potentially hazardous activities until at least 12 hours after administration for the duration of the 14-day course. Patients may not be able to assess their own driving competence or degree of impairment.
Quem deve ter cuidado
- CNS depressant effects such as somnolence and confusion; higher risk of falls; consider dose reduction or discontinuation.
- Suicidal thoughts and behavior: consider changing regimen, including discontinuing, if depression worsens or suicidality emerges.
- Embryo-fetal toxicity: may cause fetal harm; use effective contraception during treatment and for 1 week after the final dose.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (147)
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
- Carbamazepine + Zuranolone Major
- Carisoprodol + Zuranolone Major
- Chloral hydrate + Zuranolone Major
- Chlordiazepoxide + Zuranolone Major
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Perguntas frequentes
What is Zuranolone used for?
Zuranolone is a medicine in the class central nervous system. It is used for Depression.
What side effects have been reported with Zuranolone?
Somnolence, Dizziness, Diarrhea, Fatigue, Nasopharyngitis, Urinary tract infection. Serious warning: Causes driving impairment due to CNS depressant effects.
Can Zuranolone be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists. Breastfeeding: Unknown. Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.
What does Zuranolone interact with?
MediHelp lists 147 known interactions for Zuranolone. Major: 52 · Moderate: 93 · Minor: 2. The most serious include Alprazolam, Amobarbital, Apalutamide.
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