Interações medicamentosas
Butorphanol + Zuranolone
Gravidade: Grave
Butorphanol and Zuranolone: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Taken with butorphanol, CNS depression and psychomotor impairment may be greater.
O que esta interação significa em palavras simples
Butorphanol and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
Por que acontece
Additive pharmacodynamic CNS depression via GABA-A modulation and opioid receptor agonism.
O que fazer
Avoid if possible; if both are needed, consider lowering the dose of zuranolone or butorphanol. Monitor sedation and respiratory function and counsel against driving.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Butorphanol e Zuranolone, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Alfentanil + Butorphanol Grave
- Alprazolam + Butorphanol Grave
- Alvimopan + Butorphanol Grave
- Amobarbital + Butorphanol Grave
Outras interações de Zuranolone
Perguntas frequentes
Can I take Butorphanol with Zuranolone?
MediHelp rates the interaction as major. Butorphanol and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Taken with butorphanol, CNS depression and psychomotor impairment may be greater.
How serious is the interaction between Butorphanol and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, consider lowering the dose of zuranolone or butorphanol. Monitor sedation and respiratory function and counsel against driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
