Interações medicamentosas
Abacavir + Ribavirin
Gravidade: Moderada
Abacavir and Ribavirin: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
O que esta interação significa em palavras simples
Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Abacavir belongs to Anti Virals; Ribavirin belongs to Anti Virals.
Por que acontece
Possible additive mitochondrial toxicity; ribavirin may also alter intracellular nucleoside phosphorylation, though this is not firmly established for abacavir.
O que fazer
Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ribavirin
- Didanosine + Ribavirin Contraindicada
- Ribavirin + Stavudine Grave
- Ribavirin + Zidovudine Grave
- Emtricitabine + Ribavirin Leve
- Lamivudine + Ribavirin Leve
- Ribavirin + Tobramycin inhaled Leve
Outras interações de Abacavir
Perguntas frequentes
Can I take Abacavir with Ribavirin?
MediHelp rates the interaction as moderate. Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
How serious is the interaction between Abacavir and Ribavirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
What other medicines interact with Ribavirin?
MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Zidovudine. The full list is on the Ribavirin page.
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