Interações medicamentosas
Acalabrutinib + Aluminum hydroxide
Gravidade: Moderada
Acalabrutinib and Aluminum hydroxide: moderate interaction.
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Resumo
Antacids neutralise gastric acid and can lower the dissolution and absorption of acalabrutinib capsules. Reduced exposure may weaken its antitumor effect.
O que esta interação significa em palavras simples
Acalabrutinib and Aluminum hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Aluminum hydroxide belongs to Gastrointestinal Tract.
Por que acontece
Increased gastric pH reduces the pH-dependent solubility of acalabrutinib.
O que fazer
Separate the antacid and acalabrutinib capsules by at least 2 hours, or use the pH-independent tablet formulation.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Aluminum hydroxide
Outras interações de Acalabrutinib
Perguntas frequentes
Can I take Acalabrutinib with Aluminum hydroxide?
MediHelp rates the interaction as moderate. Acalabrutinib and Aluminum hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids neutralise gastric acid and can lower the dissolution and absorption of acalabrutinib capsules. Reduced exposure may weaken its antitumor effect.
How serious is the interaction between Acalabrutinib and Aluminum hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid and acalabrutinib capsules by at least 2 hours, or use the pH-independent tablet formulation.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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