Interações medicamentosas
Acetylsalicylic acid + Ticlopidine
Gravidade: Grave
Acetylsalicylic acid and Ticlopidine: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Combining aspirin with ticlopidine increases the risk of bleeding because both impair platelet function through different pathways. The pair is sometimes used deliberately, for example after coronary stenting, but ticlopidine carries additional hematologic toxicity and has largely been replaced by other agents.
O que esta interação significa em palavras simples
Acetylsalicylic acid and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Por que acontece
Additive antiplatelet effects from irreversible COX-1 inhibition by aspirin and P2Y12 receptor blockade by ticlopidine.
O que fazer
Use only when dual antiplatelet therapy is clearly indicated, and prefer clopidogrel or another P2Y12 inhibitor instead of ticlopidine. Monitor for bleeding and follow blood counts regularly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicada
- Acetylsalicylic acid + Ketorolac intranasal Contraindicada
- Abciximab + Acetylsalicylic acid Grave
- Acemetacin + Acetylsalicylic acid Grave
- Acetazolamide + Acetylsalicylic acid Grave
- Acetylsalicylic acid + Alteplase Grave
Outras interações de Ticlopidine
- Mavacamten + Ticlopidine Contraindicada
- Abrocitinib + Ticlopidine Grave
- Apixaban + Ticlopidine Grave
- Aspirin / citric acid / sodium bicarbonate + Ticlopidine Grave
- Aspirin rectal + Ticlopidine Grave
Perguntas frequentes
Can I take Acetylsalicylic acid with Ticlopidine?
MediHelp rates the interaction as major. Acetylsalicylic acid and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with ticlopidine increases the risk of bleeding because both impair platelet function through different pathways. The pair is sometimes used deliberately, for example after coronary stenting, but ticlopidine carries additional hematologic toxicity and has largely been replaced by other agents.
How serious is the interaction between Acetylsalicylic acid and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when dual antiplatelet therapy is clearly indicated, and prefer clopidogrel or another P2Y12 inhibitor instead of ticlopidine. Monitor for bleeding and follow blood counts regularly.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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