Interações medicamentosas
Adenovirus types 4 and 7 live + Cisplatin
Gravidade: Grave
Adenovirus types 4 and 7 live and Cisplatin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cisplatin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine could cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.
O que esta interação significa em palavras simples
Adenovirus types 4 and 7 live and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Chemotherapy-induced immunosuppression impairs control of live attenuated vaccine virus and reduces immune response.
O que fazer
Avoid the live vaccine during cisplatin therapy and for at least 3 months after stopping. Use only when immune recovery is confirmed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cisplatin
- Cidofovir + Cisplatin Contraindicada
- Adefovir + Cisplatin Grave
- Amikacin + Cisplatin Grave
- Amphotericin b deoxycholate + Cisplatin Grave
- Amphotericin b + Cisplatin Grave
- Bacitracin + Cisplatin Grave
Perguntas frequentes
Can I take Adenovirus types 4 and 7 live with Cisplatin?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine could cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.
How serious is the interaction between Adenovirus types 4 and 7 live and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during cisplatin therapy and for at least 3 months after stopping. Use only when immune recovery is confirmed.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Cisplatin page.
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