Interações medicamentosas
Bacitracin + Cisplatin
Gravidade: Grave
Bacitracin and Cisplatin: major interaction.
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Resumo
Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.
O que esta interação significa em palavras simples
Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Cisplatin belongs to Oncology.
Por que acontece
Additive nephrotoxicity from proximal tubular injury.
O que fazer
Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cisplatin
- Cidofovir + Cisplatin Contraindicada
- Adefovir + Cisplatin Grave
- Adenovirus types 4 and 7 live + Cisplatin Grave
- Amikacin + Cisplatin Grave
- Amphotericin b deoxycholate + Cisplatin Grave
- Amphotericin b + Cisplatin Grave
Outras interações de Bacitracin
- Bacitracin + Cidofovir Contraindicada
- Adefovir + Bacitracin Grave
- Aldesleukin + Bacitracin Grave
- Amikacin + Bacitracin Grave
- Bacitracin + Carboplatin Grave
- Bacitracin + Colistin Grave
Perguntas frequentes
Can I take Bacitracin with Cisplatin?
MediHelp rates the interaction as major. Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.
How serious is the interaction between Bacitracin and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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