Interações medicamentosas
Adenovirus types 4 and 7 live + Fludarabine
Gravidade: Contraindicada
Adenovirus types 4 and 7 live and Fludarabine: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
O que esta interação significa em palavras simples
Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Fludarabine-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
O que fazer
Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fludarabine
- Fludarabine + Pentostatin Contraindicada
- Belatacept + Fludarabine Grave
- Dengue vaccine + Fludarabine Grave
- Etrasimod + Fludarabine Grave
- Fingolimod + Fludarabine Grave
- Fludarabine + Ofatumumab sc Grave
Perguntas frequentes
Can I take Adenovirus types 4 and 7 live with Fludarabine?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Fludarabine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Pentostatin, Belatacept, Dengue vaccine. The full list is on the Fludarabine page.
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