Interações medicamentosas
Fludarabine + Pentostatin
Gravidade: Contraindicada
Fludarabine and Pentostatin: contraindicated interaction.
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Resumo
Combining these purine analogues has caused severe or fatal pulmonary toxicity in clinical use. The combination is contraindicated in labeling.
O que esta interação significa em palavras simples
Fludarabine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fludarabine belongs to Oncology; Pentostatin belongs to Oncology.
Por que acontece
The mechanism is not established, though additive purine analogue toxicity, possibly involving adenosine deaminase inhibition, is suspected.
O que fazer
Do not use together; choose a different regimen. Observe patients for respiratory symptoms if previously exposed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicada
- Belatacept + Fludarabine Grave
- Dengue vaccine + Fludarabine Grave
- Etrasimod + Fludarabine Grave
- Fingolimod + Fludarabine Grave
- Fludarabine + Ofatumumab sc Grave
Outras interações de Pentostatin
- Carmustine + Pentostatin Contraindicada
- Etoposide + Pentostatin Contraindicada
- Cyclophosphamide + Pentostatin Grave
- Deferiprone + Pentostatin Grave
- Fingolimod + Pentostatin Grave
- Nelarabine + Pentostatin Grave
Perguntas frequentes
Can I take Fludarabine with Pentostatin?
MediHelp rates the interaction as contraindicated. Fludarabine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these purine analogues has caused severe or fatal pulmonary toxicity in clinical use. The combination is contraindicated in labeling.
How serious is the interaction between Fludarabine and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different regimen. Observe patients for respiratory symptoms if previously exposed.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Fludarabine page.
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