Interações medicamentosas
Adenovirus types 4 and 7 live + Paclitaxel
Gravidade: Grave
Adenovirus types 4 and 7 live and Paclitaxel: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
O que esta interação significa em palavras simples
Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Chemotherapy-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
O que fazer
Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Paclitaxel
Perguntas frequentes
Can I take Adenovirus types 4 and 7 live with Paclitaxel?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
How serious is the interaction between Adenovirus types 4 and 7 live and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Cobicistat, Cyclosporine, Cyclosporin. The full list is on the Paclitaxel page.
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