Interações medicamentosas
Dengue vaccine + Paclitaxel
Gravidade: Grave
Dengue vaccine and Paclitaxel: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Paclitaxel-induced immunosuppression may blunt the response to the dengue vaccine. As the vaccine is live attenuated, vaccination during chemotherapy also carries a risk of vaccine-related infection.
O que esta interação significa em palavras simples
Dengue vaccine and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Chemotherapy-induced immunosuppression reduces vaccine immune response and permits replication of the live attenuated virus.
O que fazer
Avoid giving the live dengue vaccine during chemotherapy. Delay vaccination until immune recovery, as advised by the oncology team.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Paclitaxel
Perguntas frequentes
Can I take Dengue vaccine with Paclitaxel?
MediHelp rates the interaction as major. Dengue vaccine and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paclitaxel-induced immunosuppression may blunt the response to the dengue vaccine. As the vaccine is live attenuated, vaccination during chemotherapy also carries a risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine during chemotherapy. Delay vaccination until immune recovery, as advised by the oncology team.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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