Interações medicamentosas
Alendronate + Calcium carbonate
Gravidade: Moderada
Alendronate and Calcium carbonate: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
O que esta interação significa em palavras simples
Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alendronate belongs to Musculoskeletal; Calcium carbonate belongs to Gastrointestinal Tract.
Por que acontece
Divalent calcium cations form insoluble complexes with alendronate in the gastrointestinal tract, reducing absorption.
O que fazer
Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Calcium carbonate
- Acalabrutinib + Calcium carbonate Moderada
- Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate Moderada
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium carbonate Moderada
- Atazanavir + Calcium carbonate Moderada
- Atenolol + Calcium carbonate Moderada
- Azilsartan-chlorthalidone + Calcium carbonate Moderada
Outras interações de Alendronate
- Aceclofenac + Alendronate Moderada
- Acemetacin + Alendronate Moderada
- Acetylsalicylic acid + Alendronate Moderada
- Alendronate + Aluminum hydroxide Moderada
- Alendronate + Aspirin Moderada
- Alendronate + Aspirin / citric acid / sodium bicarbonate Moderada
Perguntas frequentes
Can I take Alendronate with Calcium carbonate?
MediHelp rates the interaction as moderate. Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
How serious is the interaction between Alendronate and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Calcium carbonate page.
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