Interações medicamentosas
Azilsartan-chlorthalidone + Calcium carbonate
Gravidade: Moderada
Azilsartan-chlorthalidone and Calcium carbonate: moderate interaction.
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Resumo
Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
O que esta interação significa em palavras simples
Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
Por que acontece
Thiazide-like reduction of renal calcium excretion adds to calcium load from supplementation.
O que fazer
Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Azilsartan-chlorthalidone
Outras interações de Calcium carbonate
Perguntas frequentes
Can I take Azilsartan-chlorthalidone with Calcium carbonate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
How serious is the interaction between Azilsartan-chlorthalidone and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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