Interações medicamentosas
Alfentanil + Chlordiazepoxide-clidinium
Gravidade: Grave
Alfentanil and Chlordiazepoxide-clidinium: major interaction.
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Resumo
Combining a benzodiazepine with an opioid such as alfentanil increases sedation and the risk of respiratory depression, coma and death.
O que esta interação significa em palavras simples
Alfentanil and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression.
O que fazer
Avoid unless necessary; use the lowest doses and shortest duration with continuous monitoring of respiratory status and sedation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide-clidinium
- Alprazolam + Chlordiazepoxide-clidinium Grave
- Amobarbital + Chlordiazepoxide-clidinium Grave
- Belladonna and opium + Chlordiazepoxide-clidinium Grave
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Grave
- Brexanolone + Chlordiazepoxide-clidinium Grave
- Buprenorphine buccal + Chlordiazepoxide-clidinium Grave
Perguntas frequentes
Can I take Alfentanil with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Alfentanil and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases sedation and the risk of respiratory depression, coma and death.
How serious is the interaction between Alfentanil and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless necessary; use the lowest doses and shortest duration with continuous monitoring of respiratory status and sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
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