Interações medicamentosas
Alprazolam + Chlordiazepoxide-clidinium
Gravidade: Grave
Alprazolam and Chlordiazepoxide-clidinium: major interaction.
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Resumo
Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
O que esta interação significa em palavras simples
Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Por que acontece
Additive GABA-A receptor mediated CNS and respiratory depression.
O que fazer
Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Grave
- Amobarbital + Chlordiazepoxide-clidinium Grave
- Belladonna and opium + Chlordiazepoxide-clidinium Grave
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Grave
- Brexanolone + Chlordiazepoxide-clidinium Grave
- Buprenorphine buccal + Chlordiazepoxide-clidinium Grave
Outras interações de Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Alprazolam + Sodium oxybate Contraindicada
- Alfentanil + Alprazolam Grave
Perguntas frequentes
Can I take Alprazolam with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
How serious is the interaction between Alprazolam and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
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