Interações medicamentosas
Alfentanil + Clemastine
Gravidade: Grave
Alfentanil and Clemastine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Concurrent use of an opioid with a sedating antihistamine increases sedation and may add to respiratory depression. Impaired alertness and psychomotor performance are expected, and the risk rises in older or frail patients.
O que esta interação significa em palavras simples
Alfentanil and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression through opioid receptor agonism and H1-antihistamine sedation.
O que fazer
Monitor sedation level and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine when feasible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Outras interações de Clemastine
Perguntas frequentes
Can I take Alfentanil with Clemastine?
MediHelp rates the interaction as major. Alfentanil and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of an opioid with a sedating antihistamine increases sedation and may add to respiratory depression. Impaired alertness and psychomotor performance are expected, and the risk rises in older or frail patients.
How serious is the interaction between Alfentanil and Clemastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine when feasible.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine buccal, Buprenorphine long-acting. The full list is on the Clemastine page.
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