Interações medicamentosas
Benzhydrocodone / acetaminophen + Clemastine
Gravidade: Grave
Benzhydrocodone / acetaminophen and Clemastine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Benzhydrocodone is a prodrug of the opioid hydrocodone, and combining it with a sedating antihistamine increases sedation and psychomotor impairment. Profound sedation and respiratory depression are possible, particularly at higher opioid doses or in vulnerable patients.
O que esta interação significa em palavras simples
Benzhydrocodone / acetaminophen and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from the opioid agonist and the sedating H1 antihistamine.
O que fazer
Reserve the combination for patients with no alternative, using the lowest effective doses and shortest duration. Monitor for sedation and slowed breathing, and counsel the patient to avoid driving and alcohol.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Outras interações de Clemastine
Perguntas frequentes
Can I take Benzhydrocodone / acetaminophen with Clemastine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of the opioid hydrocodone, and combining it with a sedating antihistamine increases sedation and psychomotor impairment. Profound sedation and respiratory depression are possible, particularly at higher opioid doses or in vulnerable patients.
How serious is the interaction between Benzhydrocodone / acetaminophen and Clemastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternative, using the lowest effective doses and shortest duration. Monitor for sedation and slowed breathing, and counsel the patient to avoid driving and alcohol.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Buprenorphine buccal, Buprenorphine long-acting. The full list is on the Clemastine page.
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