Interações medicamentosas
Alfentanil + Morphine
Gravidade: Grave
Alfentanil and Morphine: major interaction.
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Resumo
Combining two opioids adds to sedation, respiratory depression and hypotension. The risk is highest during dose changes, in opioid-naive patients and in the elderly.
O que esta interação significa em palavras simples
Alfentanil and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive mu-opioid receptor mediated CNS and respiratory depression.
O que fazer
Use the lowest effective doses with continuous respiratory and sedation monitoring. Have naloxone available.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Morphine
- Alvimopan + Morphine Contraindicada
- Isocarboxazid + Morphine Contraindicada
- Morphine + Olanzapine / samidorphan Contraindicada
- Morphine + Phenelzine Contraindicada
- Morphine + Tranylcypromine Contraindicada
- Alprazolam + Morphine Grave
Perguntas frequentes
Can I take Alfentanil with Morphine?
MediHelp rates the interaction as major. Alfentanil and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two opioids adds to sedation, respiratory depression and hypotension. The risk is highest during dose changes, in opioid-naive patients and in the elderly.
How serious is the interaction between Alfentanil and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses with continuous respiratory and sedation monitoring. Have naloxone available.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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