Interações medicamentosas
Alprazolam + Morphine
Gravidade: Grave
Alprazolam and Morphine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings against concomitant use unless alternatives are inadequate.
O que esta interação significa em palavras simples
Alprazolam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression through opioid receptor and GABA-A receptor activity.
O que fazer
Avoid the combination if possible; otherwise use the lowest doses and shortest duration, and monitor closely for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Morphine
- Alvimopan + Morphine Contraindicada
- Isocarboxazid + Morphine Contraindicada
- Morphine + Olanzapine / samidorphan Contraindicada
- Morphine + Phenelzine Contraindicada
- Morphine + Tranylcypromine Contraindicada
- Alfentanil + Morphine Grave
Outras interações de Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Alprazolam + Sodium oxybate Contraindicada
- Alfentanil + Alprazolam Grave
Perguntas frequentes
Can I take Alprazolam with Morphine?
MediHelp rates the interaction as major. Alprazolam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings against concomitant use unless alternatives are inadequate.
How serious is the interaction between Alprazolam and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise use the lowest doses and shortest duration, and monitor closely for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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