Interações medicamentosas
Allopurinol + Amlodipine-benazepril
Gravidade: Moderada
Allopurinol and Amlodipine-benazepril: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.
O que esta interação significa em palavras simples
Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Amlodipine-benazepril belongs to Cardiovascular.
Por que acontece
The mechanism is not established; an additive predisposition to hypersensitivity has been proposed.
O que fazer
Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicada
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicada
- Aldesleukin + Amlodipine-benazepril Grave
- Amifostine + Amlodipine-benazepril Grave
- Amiloride + Amlodipine-benazepril Grave
- Amlodipine-benazepril + Azilsartan Grave
Outras interações de Allopurinol
Perguntas frequentes
Can I take Allopurinol with Amlodipine-benazepril?
MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.
How serious is the interaction between Allopurinol and Amlodipine-benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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