Interações medicamentosas
Allopurinol + Amlodipine-perindopril
Gravidade: Moderada
Allopurinol and Amlodipine-perindopril: moderate interaction.
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Resumo
ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
O que esta interação significa em palavras simples
Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Amlodipine-perindopril belongs to Cardiovascular.
Por que acontece
The mechanism is not established; an additive hypersensitivity or immune-mediated effect has been proposed.
O que fazer
Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicada
- Amlodipine-perindopril + Protein a column Contraindicada
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicada
- Amifostine + Amlodipine-perindopril Grave
- Amiloride + Amlodipine-perindopril Grave
- Amlodipine-perindopril + Azilsartan Grave
Outras interações de Allopurinol
Perguntas frequentes
Can I take Allopurinol with Amlodipine-perindopril?
MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
How serious is the interaction between Allopurinol and Amlodipine-perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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