Interações medicamentosas
Alogliptin + Chlorpropamide
Gravidade: Moderada
Alogliptin and Chlorpropamide: moderate interaction.
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Resumo
Alogliptin alone rarely causes hypoglycemia, but with a sulfonylurea such as chlorpropamide the risk increases. Chlorpropamide's long duration can make hypoglycemia prolonged.
O que esta interação significa em palavras simples
Alogliptin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Por que acontece
Additive glucose lowering from DPP-4 inhibition and sulfonylurea-stimulated insulin secretion.
O que fazer
Consider reducing the chlorpropamide dose when alogliptin is started and monitor blood glucose for hypoglycemia.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Chlorpropamide
Outras interações de Alogliptin
- Alogliptin + Amlodipine-benazepril Moderada
- Alogliptin + Benazepril Moderada
- Alogliptin + Captopril Moderada
- Alogliptin + Captopril-hydrochlorothiazide Moderada
- Alogliptin + Dulaglutide Moderada
- Alogliptin + Gliclazide Moderada
Perguntas frequentes
Can I take Alogliptin with Chlorpropamide?
MediHelp rates the interaction as moderate. Alogliptin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alogliptin alone rarely causes hypoglycemia, but with a sulfonylurea such as chlorpropamide the risk increases. Chlorpropamide's long duration can make hypoglycemia prolonged.
How serious is the interaction between Alogliptin and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when alogliptin is started and monitor blood glucose for hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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