Interações medicamentosas
Chlorpropamide + Insulin glargine-lixisenatide
Gravidade: Grave
Chlorpropamide and Insulin glargine-lixisenatide: major interaction.
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Resumo
Chlorpropamide stimulates insulin secretion, so combining it with insulin and lixisenatide markedly raises hypoglycemia risk. Chlorpropamide has a long half-life and is renally cleared, so hypoglycemia can be prolonged, especially in older patients or those with kidney impairment.
O que esta interação significa em palavras simples
Chlorpropamide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Por que acontece
Additive glucose lowering from sulfonylurea-driven insulin secretion plus exogenous insulin and GLP-1 receptor agonism.
O que fazer
Reduce the sulfonylurea dose, or preferably switch to a shorter-acting agent, when combining with this product. Monitor glucose closely, especially with renal impairment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin glargine-lixisenatide
Outras interações de Chlorpropamide
Perguntas frequentes
Can I take Chlorpropamide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Chlorpropamide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpropamide stimulates insulin secretion, so combining it with insulin and lixisenatide markedly raises hypoglycemia risk. Chlorpropamide has a long half-life and is renally cleared, so hypoglycemia can be prolonged, especially in older patients or those with kidney impairment.
How serious is the interaction between Chlorpropamide and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the sulfonylurea dose, or preferably switch to a shorter-acting agent, when combining with this product. Monitor glucose closely, especially with renal impairment.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Dulaglutide, Ethanol. The full list is on the Insulin glargine-lixisenatide page.
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