Interações medicamentosas
Alogliptin-metformin + Entecavir
Gravidade: Moderada
Alogliptin-metformin and Entecavir: moderate interaction.
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Resumo
Entecavir, a nucleoside analogue, has been associated with lactic acidosis and severe hepatomegaly with steatosis. Metformin carries its own risk of lactic acidosis, so using both may add to that risk, particularly in patients with renal or hepatic impairment.
O que esta interação significa em palavras simples
Alogliptin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
Por que acontece
Additive risk of lactic acidosis through mitochondrial toxicity (entecavir) and impaired lactate clearance (metformin); no direct pharmacokinetic interaction is established.
O que fazer
Monitor renal and hepatic function periodically and educate the patient to report nausea, abdominal pain, malaise or rapid breathing. Check lactate and stop metformin if lactic acidosis is suspected.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Alogliptin-metformin
Outras interações de Entecavir
Perguntas frequentes
Can I take Alogliptin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir, a nucleoside analogue, has been associated with lactic acidosis and severe hepatomegaly with steatosis. Metformin carries its own risk of lactic acidosis, so using both may add to that risk, particularly in patients with renal or hepatic impairment.
How serious is the interaction between Alogliptin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal and hepatic function periodically and educate the patient to report nausea, abdominal pain, malaise or rapid breathing. Check lactate and stop metformin if lactic acidosis is suspected.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
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